Synthesis in the Erythrinane Group of Compounds. I. A Synthesis
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概要
- 論文の詳細を見る
A new synthesis of 15,16-dimethoxyerythrinane was described. 3,4-Dimethoxyphenethylamine was condensed with cyclohexane-1,2-dione in the presence of phoshoric acid to yield the basic spiroketone (II), which was converted into N-ethoxycarbonylacetyl derivative(IV') by the conventional method. The latter was cyclyzed by means of sodium hydride in boilng ethanol to give the dehydrated tatracyclic compound (VII) in a good yield. The decarboxylation product (VIII) of (VII) was reduced catalytically to furnish (IX), which on being reduced with lithium aluminum hydride gave rise to 15,16-dimethoxyery-thrinane (X).
- 公益社団法人日本薬学会の論文
- 1960-04-25
著者
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菅澤 重彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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吉川 浩
Faculty Of Pharmaceutical Sciences Osaku University
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菅澤 重彦
Research Laboratories, Tanabe Seiyaku Co. Ltd.
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吉川 浩
Research Laboratories, Tanabe Seiyaku Co. Ltd.
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菅澤 重彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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