Studies on Nepalese Crude Drugs. XXIV. Diterpenoid Constituents of the Leaves of Scutellaria repens BUCH.-HAM.ex D. DON
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概要
- 論文の詳細を見る
From the leaves of Scutellaria repens, sixteen new neoclerodane-type diterpenes named scuterepenins A_1,A_2,B, C_1,C_2,D_1,D_2,E, F_1,F_2,G_1 and G_2,and scuterepenosides A_1,A_2,A_3 and A_4,have been isolated along with a new 9,11-secoabietane-type diterpene named scuterepenin H. The structures of these compounds have been determined by spectroscopic and chemical methods as follows : scuterepenin A_1,(4R, 11S, 13R)-7β-trans-cinnamoyloxy-4,6α, 13,18-tetrahydroxy-11,16 : 15,16-diepoxy-1-neoclerodanone; scuterepenin A_2,cis-cinnamoyl form of A_1; scuterepenin B, (4R, 11S, 13R)-7β-trans-cinnamoyloxy-2α, 4,6α, 13,18-pentahydroxy-11,16 : 15,16-diepoxy-1-neocler-odanone; scuterepenin C_1,(4R, 11S, 13R)-6α-trans-cinnamoyloxy-7β, 13-dihydroxy-4,18 : 11,16 : 15,16-triepoxy-1-neoclerodanone; scuterepenin C_2,cis-cinnamoyl form of C_1; scuterepenin D_1,(4R, 11S^*, 13R^*)-6α-trans-cinnamoyl-oxy-1β, 7β-diacetoxy-11,16 : 15,16-diepoxy-18-neoclerodanal; scuterepenin D_2,cis-cinnamoyl form of D_1; scuterepenin E, (4R, 11S^*, 13R^*)-1β-acetoxy-7β-trans-cinnamoyloxy-6α-hydroxy-11,16 : 15,16-diepoxy-18-neoclerodanal; scuterepenin F_1,(4R, 11S^*, 13R^*)-1β-O-acetyl-7β-O-trans-cinnamoyl-18β-O-methyl-6α, 18 : 11,16 : 15,16-triepoxyneoclerodane-1,7,18-triol; scuterepenin F_2,cis-cinnamoyl form of F_1; scuterepenin G_1,(4R, 7R, 11S, 13R)-6α-O-trans-cinnamoyl-1,16 : 4,18 : 11,16-triepoxyneoclerodane-6,7,15-triol; scuterepenin G_2,cis-cinnamoyl form of G_1; scuterepenoside A_1,(4R, 13S^*, 16S^*)-1β-trans-cinnamoyloxy-6α-(β-D-glucopyranosyloxy)-16-methoxy-15,16-epoxy-18-neoclerodanal; scuterepenoside A_2,cis-cinnamoyl form of A_1; scuterepenoside A_3,(13S^*, 16R^*)-form of A_1; scuterepenoside A_4,(13S^*, 16R^*)-form of A_2; scuterepenin H, (5S, 10R, 13S, 14S)-13-hydroxy-7-oxo-9,11-seco-8-abieten-14,11-olide.
- 公益社団法人日本薬学会の論文
- 1998-06-15
著者
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Sugita N
Faculty Of Pharmaceutical Sciences Hokuriku University
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TOMIMORI Tsuyoshi
Faculty of Pharmaceutical Sciences, Hokuriku University
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Kizu Haruhisa
Faculty Of Pharmaceutical Science Hokuriku University
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Tomimori Tsuyoshi
Faculty Of Pharmaceutical Sciences Hokuriku University
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SUGITA Naohiro
Faculty of Pharmaceutical Sciences, Hokuriku University
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