Methanol Extracts of Hamelia patens Containing Oxindole Alkaloids Relax KCl-Induced Contraction in Rat Myometrium(Pharmacognosy)
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概要
- 論文の詳細を見る
Hamelia patens JAQC. (Rubiaceae) is a medicinal bush widely distributed in tropical areas of the American continent. It is used in Mexican Traditional Medicine for the treatment of menstrual disorders, therefore suggesting that its chemical constituents may have some effect on myometrium contractility. Physiological effects might differ due to quantitative variations in the content of alkaloids arisisng from its wide geographical distribution. To test this hypothesis, the content of oxindole alkaloids in methanol extracts of five different samples collected in Mexico was quantified by GC-MS. Each extract was assayed on contractility of estrogen-primed rat myometrium. Variations in the content of alkaloids were observed among the different samples. All samples relaxed in a concentration-dependent manner the high KCl-induced contraction in rat myometrium. Those which lack rumberine and/or maruquine displayed a higher relaxant effect than samples containing them, suggesting that these alkaloids might counteract the effects of isopteropodine. However, in contrast with verapamil, Hamelia patens metanol extracts are poor relaxants.
- 公益社団法人日本薬学会の論文
- 2004-10-01
著者
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Reyes-chilpa Ricardo
Instituto De Quimica Universidad Nacional Autonoma De Mexico Ciudad Universitaria
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Reyes-chilpa Ricardo
Hiv
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Campos Maria
Unidad De Investigation Medica En Farmacologia Hospital De Especialidades Centra Medico National Sig
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Oropeza Martha
Unidad De Investigation Medica En Farmacologia Hospital De Especialidades Centra Medico National Sig
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RIVERA Jesus
Unidad de Investigation Medica en Farmacologia, Hospital de Especialidades, Centra Medico National S
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MENDOZA Pilar
Estacion de Biologia Tropical "Los Tuxtlas," Institute de Biologia, Universidad National Autonoma de
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AMEKRAZ Badia
Departement de Chimie et Biochemie, Universite de Moncton
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JANKOWSKI Christopher
Departement de Chimie et Biochemie, Universite de Moncton
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Rivera Jesus
Unidad De Investigation Medica En Farmacologia Hospital De Especialidades Centra Medico National Sig
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Campos Maria
Unidad De Investigacion Medica En Farmacologia Centro Medico Nacional Siglo Xxi
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Mendoza Pilar
Estacion De Biologia Tropical "los Tuxtlas " Institute De Biologia Universidad National Au
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Amekraz Badia
Departement De Chimie Et Biochemie Universite De Moncton
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Jankowski Christopher
Departement De Chimie Et Biochemie Universite De Moncton
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