Relaxation of Uterine and Aortic Smooth Muscle by Glaucolides D and E from Vernonia liatroides(Pharmacognosy)
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概要
- 論文の詳細を見る
Vernonia spp. (Asteraceae) are used in herbolaria in Latin America in menstrual and stomach disorders, suggesting smooth muscle relaxing properties of some of their chemical constituents. For pharmacological support for this belief, sesquiterpene lactones glaucolides D and E were assayed on isolated rat smooth muscle. Glaucolide E proved more potent than glaucolide D to relax high KCl- or noradrenaline-induced contractions in aorta and to relax the high KCl-contraction in uterus. Hirsutinolide-type sesquiterpene lactone also was tested but displayed no effect. Relaxation of smooth muscle by structurally related sesquiterpene lactone parthenolide has been attributed mainly to the α-methylene γ-lactone moiety; because glaucolides D and E lack this functional group, their relaxant properties may rely on other alkylating sites such as C10 of the germacra-1(10),4-iene-4-epoxide skeleton.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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Jimenez-estrada Manuel
メキシコ
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Jimenez‐estrada M
National Univ. Mexico Mexico Mex
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Reyes-chilpa Ricardo
Instituto De Quimica Universidad Nacional Autonoma De Mexico Ciudad Universitaria
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Reyes-chilpa Ricardo
Hiv
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JIMENEZ-ESTRADA Manuel
Institute of Chemistry, National University of Mexico
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Campos Maria
Unidad De Investigation Medica En Farmacologia Hospital De Especialidades Centra Medico National Sig
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Oropeza Martha
Unidad De Investigation Medica En Farmacologia Hospital De Especialidades Centra Medico National Sig
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CAMPOS Maria
Unit of Medical Research in Pharmacology, National Medical Center S. XXI, Mexican Institute of Socia
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OROPEZA Martha
Unit of Medical Research in Pharmacology, National Medical Center S. XXI, Mexican Institute of Socia
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PONCE Hector
Unit of Medical Research in Pharmacology, National Medical Center S. XXI, Mexican Institute of Socia
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FERNANDEZ Jaquelina
Unit of Medical Research in Pharmacology, National Medical Center S. XXI, Mexican Institute of Socia
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TORRES Hector
Institute of Chemistry, National University of Mexico
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Ponce Hector
Unit Of Medical Research In Pharmacology National Medical Center S. Xxi Mexican Institute Of Social
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Torres Hector
Institute Of Chemistry National University Of Mexico
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Fernandez Jaquelina
Unit Of Medical Research In Pharmacology National Medical Center S. Xxi Mexican Institute Of Social
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