HIV-1 Inhibition by Extracts of Clusiaceae Species from Mexico(Pharmacognosy)

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概要

• 論文の詳細を見る

• The organic plant extracts of 21 species of Clusiaceae from Mexico were screened for anti HIV-1 reverse transcriptase activity in a non-radioactive immuno colorimetric assay. The extracts of 5 species (23.8%) exhibited significant inhibition (≥70%) of HIV-1 RT activity; of these, only 4 extracts showed reduced toxicity to human lymphocytic MT2 cells and were further tested as inhibitors of HIV-1 IHb/LAV replication in a cellular system. The best extracts were Calophyllum brasiliense (hexane) and Clusia quadrangula (CH_2Cl_2-MeOH) which inhibited HIV-1 RT (IC_<50>=29.6μg/ml and 42μg/ml), and showed an EC_<50>=92.5μg/ml and 91 μg/ml, respectively, on MT2 cells. However, only Calophyllum brasiliense hexane extract showed significant inhibition on viral replication (ED_<50>=37.1 μg/ml), while Clusia quadrangula was less active (ED_<50>=124μg/ml). These results support the idea that plant extracts represent a valuable source of potential anti HIV compounds.

• 公益社団法人日本薬学会の論文
• 2004-06-01

著者

• Jimenez-estrada Manuel

  メキシコ

• Jimenez‐estrada M

  National Univ. Mexico Mexico Mex

• Jimenez-estrada Manuel

  Faculty Of Sciences National University Of Mexico

• Basualdo Maria

  Hiv

• Reyes-chilpa Ricardo

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Ciudad Universitaria

• Reyes-chilpa Ricardo

  Hiv

• HUERTA-REYES Maira

  Institute of Chemistry, National University of Mexico

• HUERTA-REYES Maira

  Department of Natural Products, Institute of Chemistry, National University of Mexico

• SOLER Carmen

  Department of Natural Products, Institute of Chemistry, National University of Mexico

• Huerta-reyes Maira

  Institute Of Chemistry National University Of Mexico

• Soler Carmen

  Department Of Natural Products Institute Of Chemistry National University Of Mexico

• LOZADA Lucio

  AIDS Section, Institute of Biomedical Sciences, National University of Mexico

• Lozada Lucio

  Aids Section Institute Of Biomedical Sciences National University Of Mexico

関連論文

• Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense(Pharmacognosy)
• Trypanocidal Constituents in Plants 1. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in Guaco, Roots of Aristolochia taliscana
• HIV-1 Inhibitory Compounds from Calophyllum brasiliense Leaves(Pharmacognosy)
• Trypanocidal Activity and Chemistry of Several Guttiferae Species from Mexico
• HIV-1 Inhibition by Extracts of Clusiaceae Species from Mexico(Pharmacognosy)
• Methanol Extracts of Hamelia patens Containing Oxindole Alkaloids Relax KCl-Induced Contraction in Rat Myometrium(Pharmacognosy)
• Relaxation of Uterine and Aortic Smooth Muscle by Glaucolides D and E from Vernonia liatroides(Pharmacognosy)

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