Relaxant Effect of Xanthomicrol and 3α-Angeloyloxy-2α-hydroxy-13,14Zdehydrocativic Acid from Brickellia paniculata on Rat Uterus(Pharmacognosy)

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概要

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• Brickellia paniculata has been used as spasmolytic in Mexican traditional medicine. Xanthomicrol and 3α-angeloyloxy-2α-hydroxy-13,14Z-dehydrocativic acid (AAHDD) are two of the main leaf components with antispasmodic activity. However, their mechanism of action remains unknown. An in vitro comparative study between xanthomicrol and AAHDD on rat uterus precontracted by either KCl (60mM) or oxytocin (10mIU/ml) was carried out to investigate the mechanism of action of these compounds on smooth muscle. Relaxant effect was measured as median inhibitory concentration (IC_<50>) and maximal effect as maximal relaxant response (R_<max>). Xanthomicrol was significantly more potent than AAHDD in inhibiting contractions induced by KCl 60mM, whereas AAHDD was more potent than xanthomicrol in inhibiting contractions induced by oxytocin 10mIU/ml. These results suggest that xanthomicrol induces a greater blocking effect on voltage-operated calcium channels than on receptor-operated gates.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• Ponce-monter Hector

  Icsa Universidad Autonoma Del Estado De Hidalgo

• Macias Arturo

  Icsa Universidad Autonoma Del Estado De Hidalgo

• Perez Cuauhtemoc

  Departamento De Sistemas Biologicos Unidad Xochimilco Universidad Autonoma Metropolitana

• Campos Maria

  Unidad De Investigacion Medica En Farmacologia Centro Medico Nacional Siglo Xxi

• Perez Salud

  Departamento De Sistemas Biologicos Unidad Xochimilco Universidad Autonoma Metropolitana

• Zavala Miguel

  Departamento De Sistemas Biologicos Unidad Xochimilco Universidad Autonoma Metropolitana

• PONCE-MONTER Hector

  ICSA, Universidad Autonoma del Estado de Hidalgo

• MECKES Mariana

  Unidad de Investigacion Medica en Farmacologia de Productos Naturales, Centro Medico Nacional Siglo

• MACIAS Arturo

  ICSA, Universidad Autonoma del Estado de Hidalgo

• Meckes Mariana

  Unidad De Investigacion Medica En Farmacologia De Productos Naturales Centro Medico Nacional Siglo X

関連論文

• Hypoglycemic Activity of a New Carbohydrate Isolated from the Roots of Psacalium peltatum
• Methanol Extracts of Hamelia patens Containing Oxindole Alkaloids Relax KCl-Induced Contraction in Rat Myometrium(Pharmacognosy)
• Relaxant Effect of Xanthomicrol and 3α-Angeloyloxy-2α-hydroxy-13,14Zdehydrocativic Acid from Brickellia paniculata on Rat Uterus(Pharmacognosy)

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