Retinoic Acid Isomers Produce Malformations in Postembryonic Development of the Japanese Flounder, Paralichthys olivaceus(Developmental Biology)
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概要
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We previously reported that characteristic deformities were induced by retinoic acid (RA) treatment of the Japanese flounder, Paralichthys olivaceus, at 6-9 days post-hatching (dph). To evaluate the toxic potency of nuclear retinoid receptors in induction of deformities by RA, we here investigated the effects of retinoic acid isomers on postembryonic development of this species. Larvae were exposed to either 25 nM of all-frans RA (atRA), 9-cis RA (9cRA) or 13-cis RA (13cRA) at 6-9 dph. All RA isomers induced deformities in the lower jaw, caudal fin and vertebrae. In the lower jaw, growth retardation of the dentary was evident. In the vertebrae, the major abnormalities were hypertrophy of the centrum, central fusion, and an increase in the number of abdominal vertebrae. Caudal fin deformities included deformity of caudal bone complex and absence of the entire caudal fin. The absence of the hypural primordium at 12 dph was the first sign of abnormality in caudal fin development, and resulted in complete blocking of the caudal fin development. Among the RA isomers, atRA induced the most severe deformity in all skeletons examined. Retinoic acid receptor (RAR) expression was activated by atRA and 9cRA, and pitx2 expression was inhibited in the lower jaw by atRA and 9cRA. Vitamin D receptor (VDR) expression was specifically inhibited by atRA treatment, suggesting that RA inhibits the lower jaw growth by suppressing the expression of these genes. These results suggest that RA exerted toxic effects on the skeletal systems, mainly through the RAR pathway.
- 社団法人日本動物学会の論文
- 2002-10-25
著者
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HAGA Yutaka
Department of Marine Biosciences, Tokyo University of Marine Science and Technology
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TAKEUCHI Toshio
Department of Marine Biosciences, Tokyo University of Marine Science and Technology
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Haga Yutaka
Tokyo Univ. Marine Sci. And Technol. Tokyo Jpn
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Haga Yutaka
Department Of Marine Biosciences Tokyo University Of Marine Science And Technology
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Haga Yutaka
Department Of Aquatic Biosciences Tokyo University Of Marine Science And Technology
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Haga Y
Center Of Marine Biotechnology University Of Maryland Biotechnology Institute
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Suzuki Tohru
National Inst. Of Material Sci.
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Suzuki T
Department Of Urology Gunma Cancer Center
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Takeuchi Toshio
Department Of Aquatic Biosciences Tokyo University Of Marine Science And Technology
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Tanigaki Taketo
Department Of Zoology Faculty Of Science Kyoto University
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Takeuchi T
Department Of Aquatic Biosciences Tokyo University Of Marine Science And Technology
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Takeuchi Toshio
Department Of Aquatic Biosciences Tokyo University Of Fisheries
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Takeuchi Toshio
Department Of Aquatic Biosciences Faculty Of Fisheries Tokyo University Of Fisheries
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