両棲類幼生のメラニン形成に及ぼすフエニール・チオ尿素の影響I

概要

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Remarkable whitening of the larvae of Rhacophorus schlegelii var. arborea Okada et Kawano, Rana nigromaculata nigromaculata (Hallowell) and Hynobius nebulosus (Schlegel) is brought about by rearing in 0.001% phenylthiocarbamide (PTC), one of the common antithyroid drugs. The treated animals become slowly colored in the tap water. All tails regenerated in PTC are colorless and those regenerates in the tap water become pigmented, whether the larvae suffered the pretreatment of PTC or not. Histological study shows a remarkable decrease of melanin contents in the skin of the treated animals. As for the melanophores, however, no significant difference is found in their distribution and number. The same results can be obtained as to the visceral melanophores. The melanophore develops normally in the explant of the neural plate, cultured in 0.00015% PTC-Holtfreter's solution, though there are found only a few melanin granules in both melanophore and epidermal cell. From the facts above mentioned, the author concludes that the pallor produced by PTC treatment is not dependent on and disturbance of thyro-pituitary function, but that there is independent process, probably resulting from the tyrosinase inhibition in the melanophores.
社団法人日本動物学会の論文
1955-09-15