エールリツヒ腹水癌(マウス)の核學的研究

概要

論文の詳細を見る
The present paper deals with the chromosomal chracteristics of the tumor cells in the Ehrlich ascites tumor of mice. The results obtained are summarized as follows:-(1) Frequencies in occurrence of the diploid (±2n), tetraploid (±4n) and hyperploid cells (>±4n) are shown in Table 1. The tetraploid cells appeared in the highest frequency showing 96 per cent. Evidence suggests that the tumor stem cells which are the primary contributors to the formation of the tumor are of tetraploid nature. (2) Relative frequencies of the tumor cells undergoing regular mitosis and those showing various abnormalities which occurred in the tetraploid cells were observed with the daily material in a tumor mouse through 12 days of its whole life span (Table 2). The results give a supplemental proof indicating that the cells multiplying regularly with subtetraploid chromosomes primarily participate in the growth of the tumor. (3) The results of chromosomes countings undertaken in 26 metaphase plates are shown in Table 3. The chromosome numbers showed a wide range of variation, but the cells having ±75 chromosomes were highest in frequency. (4) The chromosome complex of the tumor stem cells is characterized by the presence of the V-shaped chromosome of medium size. The V-element was one in occurrence in most of the cells observed, with a few exceptional cells including two V's.
社団法人日本動物学会の論文
1954-01-15