ヒト早期胃癌及び各種胃疾患におけるDNAの細胞光学的研究

概要

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The DNA content of individual cells in abnormal stomachs was estimated by Feulgen microspectrophotometry (Two-wavelength method), in comparison with that of normal stomachs or coexistent normal tissue, adjacent to or distant from the abnormal site. The results obtained were as follows: 1) The constancy of nuclear DNA in cells of normal stomachs and gastritises accompanied by duodenum ulcer was confirmed. 2) No remarkable deviation of DNA content was found in coexistent distant tissues of gastric polyps, gastric ulcers and early gastric carcinomas. 3) In four of fourteen cases of chronic gastritises and in three of ten polyps, abnormal DNA content was found. In one of eleven cases of gastric ulcers studied, regenerating tissue showed a slight increase in DNA content. 4) In nine of ten early gastric carcinomas which were compared with coexistent normal distant cells, abnormal pattern of DNA content was obtained. One case shwoed abnormal amount of DNA in only coexistent adjacent normal tissue, and four cases, only in tumorcells. The other four cases, however, showed abnormal increase of the amount of DNA in both tumor and coexistent adjacent cells.
社団法人日本動物学会の論文
1968-12-15