マウスの営巣行動に対するProgesteroneおよびProlactinの役割について

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Virgin female mice of the strain IVCS, 8 to 12 weeks of age, were housed individually. A preweighed amount of pine wood wool in a receptacle was immediately placed on the cage tops at 1000 hour. The mice were allowed to build nests over a 24hour period. On the following morning, the material remaining in the receptacle was weighed and replenished. 1) Female mice with pup exposure showed significant increases in nest weight and percentage of good-excellent nest building, while males did not respond. Gonadectomized females and males with pup exposure showed similar results. 2) All of the hypophysectomized female mice with pup exposure showed a reduction maternal nest building. 3) Female mice with the male pituitary gland grafted under the capsule of the left kidney could be induced to construct a brood nest, while females administered ovineprolactin could not be induced. 4) Plasma progesterone concentrations determined by radioimmunoassay in female mice with grafted pituitary glands or in those who received ovine-prolactin were significantly higher than (p<0.001) that in virgin mice. Contrary to these data, serum mouse-prolactin levels determined by RIA in the pituitary-grafted mice were significantly higher than (p<0.001) that in ovine-prolactin-treated females. 5) The administration of the dopamine agonist, 2-Br-α ergocriptin (bromocriptine;cb-154), blocked the elevation of serum levels of mouse-prolactin in pseudopregnant mice. Following the reduction of mouse-prolactin levels, the maternal nest building in the female was immediately interrrupted by CB-154 treatment. At this time, however, plasma progesterone levels did not yet decrease. The reduction of progesterone levels occurred 2 days after CB-154 Treatment. We suggest that mouse-prolactin itself promotes maternal nest building in the mouse, and activated nest building observed in progesterone-treated females should be the result of the increased secretion of animal endogenous prolactin induced by progesterone.
社団法人日本動物学会の論文
1983-09-25

マウスの営巣行動に対するProgesteroneおよびProlactinの役割について

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