Characterization of the Effects of Opsonins in Normal Hagfish Serum on the Ingestion of Rabbit Erythrocytes by Hagfish Macrophages
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概要
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Normal serum from the hagfish Eptatretus burgeri strongly enhanced the phagocytic activity of homologous peritoneal macrophages against rabbit erythrocytes (RRBC). Such phagocytosis was effectively but incompletely inhibited by rabbit antibodies against hagfish C3 (HC3). However, when RRBC were pretreated with purified HC3 or normal hagfish serum in the presence of EDTA, little enhancement of ingestion was observed. The results indicate that HC3 binds to RRBC, in collaboration with other serum factor (s), and that bound HC3 functions as an opsonin. Additionally, we obtained evidence for the possible presence of another opsonin (HOP) that was resistant to EDTA in C3-depleted hagfish serum. HOP prepared from plasma had a molecular mass of approximately 1, 000 kDa, consisting of various small polypeptides that were able to form aggregates via disulfide bonds and/or noncovalent interactions. The functions of HC3 and HOP might be essential to immunity in hagfish because no clear evidence for the production of antibodies in cyclostomes has been reported to date.
- 社団法人日本動物学会の論文
著者
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Fujii Tamotsu
Department of Health Science, Faculty of Human and Environmental Science, Hiroshima Prefectural Wome
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Fujii Tamotsu
Department Of Health Science Faculty Of Human Life And Environmental Science Hiroshima Women's
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TOMONAGA SUSUMU
School of Allied Health Sciences, Yamaguchi University
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NAKAMURA Ken-ichi
Department of Materials Science and Technology, Graduate School of Engineering Sciences, Kyushu Univ
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Kusano Toshihisa
Department Of Biology Faculty Of Science Tokyo Metropolitan University
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Tomonaga Susumu
School Of Allied Health Sciences Yamaguchi University
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SUGAWARA Yoshiaki
Department of Health Science, Prefectural University of Hiroshima
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Kunisada Satomi
Department of Health Science, Faculty of Human Life and Environmental Science, Hiroshima Women's Uni
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Fujii Reiko
School of Allied Health Sciences, Yamaguchi University
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Nakamura Toshihiro
Nippon Institute for Biological Science, Ohme
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Sekizawa Aya
Junior College Section, Seitoku University
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Fujii Reiko
School Of Allied Health Sciences Yamaguchi University
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Sekizawa Aya
Junior College Section Seitoku University
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Kunisada Satomi
Department Of Health Science Faculty Of Human Life And Environmental Science Hiroshima Women's
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Sugawara Yoshiaki
Department Of Health Science Faculty Of Human Life And Environmental Science Hiroshima Women's
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Nakamura K
Shimane Univ. Matsue Jpn
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Nakamura Ken-ichi
Department Of Clinical Pathology Tokyo Metropolitan Institute Of Gerontology
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Nakamura Ken-ichi
Department Of Chemistry Faculty Of Science Kyushu University
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Nakamura Ken-ichi
Department Of Applied Chemistry Graduate School Of Science And Engineering Ehime University
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Nakamura Toshihiro
Nippon Institute For Biological Science Ohme
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