Immunohistochemical Study of Ontogeny of Pituitary Prolactin and Growth Hormone Cells in Xenopus laevis

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The ontogeny of prolactin (PRL) and growth hormone (GH) cells in the pars distalis of Xenopus laevis was examined immunohistochemically using anti-bullfrog PRL serum and anti-bullfrog GH serum. Immunoreactive PRL and GH cells first appeared simultaneously at Nieuwkoop and Faber (NF) stage 42, in the anterodorsal region and in the central region of the pars distalis, respectively. Immunoreactive PRL cells increased moderately as metamorphosis progressed. They were distributed mainly in the anterior portion of the pars distalis. Immunoreactive GH cells showed a marked increase in number at NF stages 50-52 and NF stages 62-64 and a slight decrease at the end of metamorphosis. Throughout late premetamorphosis, prometamorphosis and climax, the GH cell number always exceeded the prolactin cell number. GH cells were situated in the posterior portion of the pars distalis. Examination of consecutive sections stained alternately with anti-PRL and anti-GH did not reveal colocalization of PRL and GH at any stage of development.
社団法人日本動物学会の論文
1994-02-15