急性薬物中毒に対する血液浄化法

概要

論文の詳細を見る
Many patients are hospitalized for acute poisoning caused by therapeutic drugs and pesticides, and most deaths result from paraquat and/or diquat (PQ/DQ) poisoning. During a period of 10 years, we applied extracorporeal elimination techniques to 95 patients, of which PQ/ DQ caused 64% and organophosphorus accounted for 11.6% PQ/DQ poisoning remains to be the most significant in the management of acute poisonings. Our studies indicated that direct hemoperfusion (DHP) enhanced the clearance of PQ more than forced diuresis in patients with a severity index of PQ poisonins (SIPP) of 81.8 μg・hr/ml and achieved more clearance of plasma than plasmaperfusion (PP) or continuous hemofiltration (CHF). DHP is the most effective elimination technique for PQ/DQ poisoning, but is difficult to repeat continuously because of adverse reaction of thrombocytopenia ; thus PP, CHF or continuous hemodiafiltration (CHDF) should be applied after continuous DHP. Extracorporeal elimination techniques can enhance the clearance of drugs and toxins, but it remains unclear if these techniques improve the clinical outcome of patients suffering from acute poisoning. Further studies are required to confirm the clinical effectiveness of extracorporeal elimination techniques.
日本アフェレシス学会の論文
1999-02-28