小児巣状糸球体硬化症由来のネフローゼ症候群における血漿交換療法

概要

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Low-density lipoprotein apheresis (LDL-A) has been tried for over 10 years in the treatment of patients with steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS). In this paper, the therapeutic roles of LDL-A in children with steroid-resistant primary FSGS are reviewed. The effects of the combination of LDL-A and prednisolone on renal injury seen in patients with steroid-resistant FSGS can be summarized as follows : 1) improvement in steroid sensitivity that may be impaired in the hyperlipidemic state, and 2) improvement in impaired glomerular function that is caused by the altered balance of glomerular vasoactive substances. Although the role of LDL-A deserves to be assessed further, LDL-A is likely be included in the choice of treatment modalities that are available for childhood patients with steroid-resistant primary FSGS.
日本アフェレシス学会の論文
1998-05-31