アフェレシスに用いられている物理的原理

概要

論文の詳細を見る
Several kinds of apheresis therapies have been developed to remove pathogenic substances related to some diseases, such as an autoimmune disease. These therapies are based on technologies, centrifugation, membrane separation, and adsorption that have been utilized in blood purification therapies for renal failure patients. Membrane plasma separation strongly depends on the concentration polarization of formed elements, mainly erythrocytes. The erythrocyte polarization model, therefore, is often applied to explain the transport of some kind of proteins through the membrane of the plasma separator. Water permeability and separative properties of the membrane plasma fractionator, which is utilized as secondary filter in double filtration plasmapheresis (DFPP), are often explained by a gel polarization model. There is a limitation in the plasma fractionation between albumin and some immunoglobulins associated with toxins related to autoimmune diseases, because none of the currently available plasma fractionators has a strict cutoff property for these proteins.
日本アフェレシス学会の論文
2002-02-28