アミロイドーシス

概要

論文の詳細を見る
Amyloidosis may be defined as the extracellular deposition of the fibrous protein amyloid in one or more sites of the body. This protein has unique ultrastructural properties, x-ray diffraction, and biochemical characteristics. It may grossly involve any organ system of the body and may thus lead to severe pathophysiologic changes, or the disorder may fall between these two extremes. The following clinical classification has been accepted by most of authors: (1) primary amyloidosis, (2) secondary amyloidosis, (3) heredofamilial amyloidosis, (4) local amyloidosis, (5) hemodyalisis related amyloidosis. No spencific therapy exists for any variety of amyloidosis. Rational therapy should be directed at the following: (1) DMSO, (2) colchicine, (3) apheresis. For primary or secondary amyloidosis, double filtration plasmperesis (DFPP) may be effective, because DFPP can move SAA. For hemodyalisis related amyloidosis, adsorption column that is made by alkyl chain is used.
日本アフェレシス学会の論文
2001-05-30