EXPERIMENTAL CALCIUM-MAGNESIUM DEFICIENCY IN RATS : CHEMICAL AND HISTOCHEMICAL STUDY

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Chemical and histochemical profiles of central nervous system tissues, skeletal and cardiac muscles and visceral organs of experimental calcium-magnesium deficient rats and control animals were studied. Six to eight weeks after a feeding schedule of a calcium-magnesium deficient diet, the calcium concentration in the kidney increased twenty-five fold over that of the control and there was a moderate increase in the spinal cord and skeletal muscle. Fluctuation of the magnesium concentration was insignificant. A decrease in succinic dehydrogenase activity demonstrated in the cerebral cortex, cerebellum, spinal cord, kidney and skeletal muscle corresponds to tissue morphology, for example, atrophy and a decreased SDH type II muscle fiber was noted in gastrocnemius tissue specimens. Acetylcholinesterase activity in the motor end-plate of the gastrocnemius muscle showed a slight decrease in enzyme activity and a swelling of the motor end-plate. The severe histochemical changes of SDH and acid phosphatase activities in renal tubules and hepatic parenchymal cells suggest a progression of cellular catabolism related to lysosomal enzyme activity.
日本組織細胞化学会の論文