敗血症性多臓器不全の病態とサイトカイン,内因性大麻(<特集>多臓器不全とアフェレシス)

概要

論文の詳細を見る
It is recognized that various humoral mediators are involved in the pathophysiology of septic shock and septic multiple organ failure (MOF) following severe sepsis. An immediate mediator, endogenous cannabinoid generated by activated monocytes/macrophages during septic shock, causes septic shock and adjusts production of other early mediators. Early mediators, especially cytokines, play a key role in the pathophysiology of septic MOF. Cytokine balance, the ratio of inflammatory cytokines and anti-inflammatory cytokines, reflects the biological response to severe sepsis. Direct hemoperfusion with polymyxin B immobilized fiber (PMX-DHP) brings about an improvement of circulation and a correction of cytokine balance with adsorption of endogenous cannabinoid. Hence PMX-DHP is an efficient therapy for patients with septic shock and septic MOF by providing a suitable humoral mediator modulation.
日本アフェレシス学会の論文
2004-02-29