HELLP症候群(<特集>多臓器不全とアフェレシス)

概要

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HELLP syndrome is a pregnancy-related disease, defined as the presence of hemolysis, elevated liver enzymes, and low platelet count. Because of its high morbidity and mortality rate for mothers and babies, much effort have been focused on understanding this disease since Weinstein's report. Recently, it has been commonly thought that HELLP syndrome comprises thrombotic microangiopathy together with thrombotic thrombocytopenia and hemolytic uremic syndrome. Moreover, apheresis and high-dose corticosteroid therapy have been proposed as treatments for HELLP syndrome. As so, there have been striking advances in knowledge about HELLP syndrome, however, many problems remain to be elucidated. We here describe the etiology, pathophysiology, diagnosis, and treatment of HELLP syndrome based on a literature review and our experiences.
日本アフェレシス学会の論文
2004-02-29