線溶活性の組織化学的研究 : 動物種属間における正常膀胱壁のtissue plsminogen ctivator

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Continuing our studies on the biochemical and histochemical distribution of fibrinolytic activity in the various epithelial cells, we wish to report comparative observations on the localization of tissue plasminogen activator in the normal bladder wall of mice, rats, guinea pigs and rabbits which are widely used in experimental studies using the histochemical fibrin slide techniqe. A few similar histochemical comparative study deals with rat and human bladder wall. Such a study is of particular interest because the transitional epithelium cells of urinary tract has a special role in physiology of hibrinolytic systems. In all instances, the same sequence of fibrinolytic activity was demonstrated, rats and guinea pigs being highly active, rabbit less so and mice only weakly active ; the fibrinolytic activity was found in relation to some vessels in the muscular coat or the submucosa, the transitional epithelial lining and the desquamated cells of all animals studied. These findings were practically similar pattern with the localization of fibrinolytic activity in the bladder wall of rat and man as described recently.
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