Cellular plasminogen activatorの組織化学的研究 : Guinea pigの正常膀胱移行上皮細胞におけるplasminogen activator

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Fibrinolytic activity in tissues is chiefly caused by a cellular activator which converts a humoral zymogen, plasminogen, to the blood proteinase, plasmin (enzyme classification number 3.4.4.14). The content of this tissue activator in various organs and tissues differs among animal species and shows wide individual variations2)4). Studying human tissues by a histochemical method, Todd81) observed that the tissue plasminogen activator was related to vascular endothelial cells. He reported serosal cells and the bladder epithelium to be inactive81). Later, several studies of Astrup and his collaborators have shown that surface epithelial cells from many orgnas are fibrinolytically active and that serosal cells may be weakly active. Glandular epithelium was usually found inactive. Prominent among the fibrinolytic epithelial cells are those of the mucosa of the urinary bladder. High activity was observed in the bladder of man, rat, guinea pig, mouse and even in the rabbit26)87)45).
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