膀胱癌化学療法についての研究 : 第5報 : 制癌剤内腸骨動脈内持続注入療法および膀胱内注入療法における制癌剤の血中動態についての実験的研究

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The blood concentration of the Mitomycin C in various vessels (artery, vena iliaca communis: infusion side and opposite side, vena portae and vena cava inferior: bifurcations of vena renalis and vena hepatica) were studied in two groups of dogs administratered as follows; Group 1. Continuous injection into the internal iliac artery (1mg/kg/24 hours) Group 2. Infusion into the lumen of urinary bladder (1mg/kg kept intravesically for 90 minutes) The results were as follow: 1) In group 1, the concentration of the agent in vena iliaca communis of infusion side (O.144mcglml) reached the highest level 6 hours after the beginning of injection and then kept constant following 18 hours. The same results were observed in the other vessels although the concentrations were lower. 2) In group 2, the concentration of the agent in vena iliaca communis (0.064mcg/ml) reached the highest level 90 minutes after infusion and 0.006mcg/ml 6 hours after infusion. But the agent could not be detected in the other vessels 6 hours after infusion.
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