膀胱癌化学療法についての研究 : 第3報制癌剤内腸骨動脈内持続注入療法が膀胱癌ならびに膀胱上皮細胞核内DNA量に及ぼす影響についての研究

概要

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Five cases of bladder cancer were treated with continuous infusion of Mitomycin C into the internal iliac artery. The histological changes of the cancer cells and DNA content in nucleus were studied. 1) No relationship between histological malignancy and DNA content was found. 2) In four cases, decrease of DNA content with diminution in the range of DNA distribution and shift of the peak to the left was noted after the administration of Mitomycin C in the amount of 70-80 mg. 3) Histological changes did not always parallel to changes of the DNA content. Histological changes and DNA content in nucleus of canine bladder epithelium were studied in four groups administered 1 mg/kg of Mitomycin C as follows, Group 1. Systemic administration Group 2. One shot injection into the internal iliac artery Group 3. Infusion into the lumen of the urinary bladder Group 4. Continuous injection into the internal iliac artery 1) No definite morphological changes were shown in groups 1 and 2, whereas atrophy, flattening and exfoliation of epithelial cells were revealed in groups 3 and 4. 2) DNA content in the nucleus of epithelial cells showed no changes in groups 1 , 2 and 3 but decreased in group 4.
社団法人日本泌尿器科学会の論文