膀胱癌化学療法についての研究 : 第4報制癌剤各種投与法における尿中排泄ならびに腎への影響についての実験的研究

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The renal excretion of the agent and the changes in renal tissue were studied in four groups of doga administered 1mg/kg of Mitomycin C as follows, Group 1 . Systemic administration Group 2. One shot injection into the internal iliac artery Group 3. Infusion into the lumen of the urinary bladder Group 4. Continuous injection into the internal iliac artery The results were as follows : 1) The concentration in systemic blood was highest at 5 minutes after administration in group 1 and 2, fal ling rapidly afterward. In group 3, the agent could not be detected after 5 minutes and thereafter only a trace was found in systemic blood. In group 4, the systemic blood concentration rose slowly for 6 hours and then kept following 18 hours. 2) From 25 to 30 per cent of total amount of administered drug were recovered in 24 hour urine in groups 1 , 2 and 4, while 6 per cent was recovered in group 3. The rate of renal excretion of the agent was not always parallel to blood concentration. 3) Histologically, swelling of glomerulus and epithelium of the proximal tubules were revealed in groups 1 and 2 at 90 minutes after administration, but generally recovered after 24 hours. In group 3, no histological changes were found. In group 4, swelling of glomerulus, atrophy of tubular cells and edema of renal medulla were found. 4) Activities of alkaline phosphatase and succinic dehydrogenase in renal tissue were normal in all groups. Activities of acid phosphatase, lactic dehydrogenase, glucose-6-phsphate dehydrogenase and monoamine oxidase decreased in groups 1, 2 and 4, most suppressed in group 4.

膀胱癌化学療法についての研究 : 第4報制癌剤各種投与法における尿中排泄ならびに腎への影響についての実験的研究

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膀胱癌化学療法についての研究 : 第4報 制癌剤各種投与法における尿中排泄ならびに腎への影響についての実験的研究

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膀胱癌化学療法についての研究 : 第4報制癌剤各種投与法における尿中排泄ならびに腎への影響についての実験的研究