膀胱癌化学療法についての研究 : 第2報制癌剤内腸骨動脈内持続注入療法についての実験的研究

概要

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In the treatment of cancer of the urinary bladder, effects and side effects of anticancer agent through various routes of administration were studied. 1) In four groups of dogs, 1 mg/kg of Mitomycin C was administered as follows; Group 1. Systemic administration Group 2. One shot injection into the internal iliac artery Group 3. Infusion into the lumen of the urinary bladder Group 4. Continuous injection into the internal iliac artery 2) Mitomycin C was demonstrated in the bladder tissue in low concentration in groups 2 and 4, but not at all in groups 1 and 3. 3) Concentration of Mitomycin C in blood followed the order of group 1, 2, 4 and 3. 4) The phosphorylase and succinic dehydrogenase activity in the bladder tissue showed decrease in the order of group 4, 2, 3 and 1. 5) Side effects were noted to be severe in the order of group 1, 2, 4 and 3. 6) Continuous infusion of anticancer agent into the internal iliac artery gave the most intense destructive effects on bladder tissue with relatively mild systemic side effects, representing a reasonable method of administration of anticancer agent.
社団法人日本泌尿器科学会の論文