膀胱癌化学療法についての研究 : 第1報制癌剤内腸骨動脈内持続注入療法についての臨床的研究

概要

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Favorable results were obtained in the treatment of 13 cases of cancer of urinary bladder (including 4 cases of relapse) with continuous infusion of anticancer agent into the internal iliac artery. 1) A polyethylene tube was inserted in retrograde fashion from the branch of the femoral artery on the side of the tumor and was ledvia external iliac artery into the internal iliac artery. The tip was placed directly above the point of branching of superior, cysticartery. Mitomycin C, 2-5mg/day, was continuously infused through this, giving the total of 50-168 mg. 2) In 3 cases, the tumor disappeared, a marked shrinkage was seen in 7, and slight shrinkage was found in 3. 3) Histologically, tumor cells revealed ballooning of the protoplasm, vacuolar degeneration, nuclear pyknosis and karyorrhexis, interstitial edema and proliferation. 4) When the dose of Mitomycin C went beyond 80 mg, anemia, leukopenia, skin ulcer in the gluteal area, and pares is of lower extremities tended to develop, In cases in which the superior gluteal artery was ligated, local side effects were mild. 5) In 4 of 13 cases, fatal outcome occurred due to intestinal hemorrhage, and death due to corpulmonale occurred in 1. In other 11, no relapse was seen over a period of 1-2 years. 6) This treatment combined with TUR effectively prevented the relapse of the tumor.
社団法人日本泌尿器科学会の論文