Epinephrine 含有 Lidocaine の口腔内投与が循環動態, 特に脳血流に及ぼす影響に関する研究

概要

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In order to investigate the effect of epinephrine on cerebral circulation, the circulatory response after oral injection of lidocaine with epinephrine was examined. Two percent lidocaine with 1 : 80, 000 epinephrine was injected in oral mucosa of dogs under pentobarbital anesthesia, and the changes of blood flow in the aorta, the coronary artery and the carotid artery were observed by electromagnetic flowmeter. The results were as follows : 1. The flow rate of the carotid artery decreased transiently after injection of 2% lidocaine with 1 : 80, 000 epinephrine, however the flow rate of the aorta and coronary artery increased. 2. The maximum decrease in the carotid arterial blood flow was observed 2 minutes after oral injection. 3. The decreasing rate of the carotid arterial blood flow after oral injection depended on the dose of epinephrine. 4. After 2% lidocaine with 1 : 80, 000 epinephrine injection, the plasma concentration of epinephrine increased rapidly and reached near the highest level after 2 minutes.
九州歯科学会の論文
1981-05-25