アナフィラキシーショックとビタミンB_2代謝に関する研究 : (I)アナフィラキシーショック誘発注射に伴なう血中ビタミンB_2濃度の変動

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Injection of horse serum caused an anaphylactic shock on guinea pigs. Changes of the blood riboflavin level, taken out by cardiocentesis were observed. Within 10-20 minutes after the injection, the total riboflavin level in the blood decreased by 1.2-3.5 μg/dl, while the level of ester form decreased by 2.0-4.3 μg/dl. Within the next 120 minutes, each was nearly restored to the value before the shock. Namely in this case, riboflavin level rather increased slightly. Free riboflavin was administered 15 or 30 minutes before, and shortly after the injection of horse serum. In such cases, the total and esterified riboflavin level decreased by 5.0-7.4 μg/dl and 7 μg/dl, respectively. In mild cases or animals which survived for a relatively long time, the decrease of free riboflavin was remarkable. It seemed that the above-mentioned changes of the vitamin levels are related to histamine.
日本ビタミン学会の論文