抗生物質投与時のラットの低プロトロンビン血症に対するビタミンK_2の効果

概要

論文の詳細を見る
Daily administration of 300mg/kg of latamoxef to rats fed a vitamin K deficient diet from 7 days to 9 days induced severe hypoprothrombinemia. The extrinsic and intrinsic coagulation activities in the latamoxef treated rats were decreased in higher degree than those in the rats fed a vitamin K deficient diet alone. Single oral administration of 0.1 or 1mg/kg of vitamin K_2 to the hypoprothrombinemic rats improved their coagulation activity. The coagulation activity was normalized completely by oral administration of 0.1mg/kg vitamin K_2 once a day for 2 days. These results suggest that latamoxef aggravates vitamin K deficiency and causes severe hypoprothrombinemia.
日本ビタミン学会の論文
1988-06-25