ワルファリン投与低プロトロンビン血症ラットでのメナキノン-4とメナキノン-7の効力比較

概要

論文の詳細を見る
The restoring effect of MK-4 on the extrinsic coagulation activity was compared with that of MK-7 using hypoprothrombinemic rats induced by warfarin. With regard to oral administration, both MK-4 and MK-7 dose-dependently enhanced the coagulation activity, but the effect of MK-4 was observed more rapidly at 1 mg/kg body weight and more potently at all dosages examined than that of MK-7. In intravenous administration, the activity of MK-4 was the same as for oral administration. On the other hand, the concentration of MK-4 in liver was lower than that of MK-7 in both oral and intravenous administrations. These results suggest that MK-4 is more active than MK-7 in the production of vitamin K-dependent coagulation factors.
日本ビタミン学会の論文
1987-12-25