ニコチン酸構造類似体としてのピリダジン-3-カルボン酸のバクテリアにたいする作用 : (I)Lactobacillus arabinosus17-5およびEscherichia coli Bにおけるピリダジン-3-カルボン酸とニコチン酸の拮抗

概要

論文の詳細を見る
Pyridazine-3-carboxylic acid (Pyd-3-CA), which is an analogue of nicotinic acid (NiA), inhibits competitively the growth of Lactobacillus arabinosus 17-5,and the inhibition index exhibits about 2200. On the other hand, it inhibits noncompetitively the growth of Escherichia coli B, which is able to synthesize NiA by itself. The later inhibition is, however, recovered only by NiA or nicotinamide (NAA), and is similar to the action of 6-aminonicotinamide (ANAA) known as the most potent antagonist of NAA. Pyd-3-CA is slightly less potent than ANAA for E. coli B, but it is interesting that, while the inhibition by ANAA is more effectively recovered by NAA than NiA, in the case of Pyd-3-CA the recovery of the inhibition by NiA is rather more than by NAA.
日本ビタミン学会の論文
1966-12-25