Thiamine Anhydride : (VII)Thiamine Anhydrideの酸化成績物とシロネズミ代謝物の比較

概要

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Oxidation of thiamine anhydride by hydrogen peroxide resulted in its sulfoxide (I) or sulfone (II) according to the reaction media. The authentic specimens of I and II were prepared, and checked both by elementary analysis and by infra-red spectrography. Both I and II show the same mp. of 132℃ and the mixture of I and II also indicates the same melting point. But after drying the samples at 60℃ for more than 60 hours, the both specimens were elevated to mp. of 177℃ (I) and of 155℃ (II). Furthermore, PbO_2-oxidation of TA, I and II revealed different degrees of PbO_2 consumption which were measured by polarography. TA, I and II each consumed about 3,2 and 1 atoms of oxygen after one hour of the reaction, The metabolite isolated from the urine of rats after intraperitoneal injection of TA also indicated the same picture of PbO_2-consumption as I. Therefore the metabolite which coincided with I as shown in the previous paper, was proved as I.
日本ビタミン学会の論文
1962-09-25