肝障害時の肝Coenzyme Q含有量

概要

論文の詳細を見る
CoQ, which is one of cafactors of the terminal oxidation system in liver cells, was measured by spectrophotometric method of Morton et al., using column chromatography. Acute CCl_4 poisoning caused a significant decrease of CoQ content of fresh liver in rats, whereas such decrease could not be found in chronic CCl_4 poisoning. In the intracellular distribution of CoQ, it is localized mainly in the mitochondrial fraction. The amounts of CoQ in the mitochondria of acute and chronic CCl_4 poisoned livers remarkably decreased compared with normal liver. It was found that rat liver contains mainly CoQ_9,although small amount of CoQ_7,CoQ_8 and CoQ_<10> are detected by paperchromatography in the mitochondrial fraction. Hepatic content of CoQ in cadavers had no difference between sex, young and old nor with and without liver diseases.
日本ビタミン学会の論文
1964-01-25