糖尿病の糖質酸化機転に関する研究:1. 糖尿病患者のαケト酸代謝

概要

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It is well known that the endocrine imbalance in diabetes mellitus causes metabolic disturbances not only of carbohydrate, but also of protein and lipids. However, in the treatment of diabetic patients, the importance of hyperglycemia and glycosuria as therapeutic guide has been too much emphasized, so that other metabolic abnormalities have often been neglected. In order to control these patients more satisfactorily, the metabolism of α-keto acids and the activity to acetylate para-aminobenzoic acid (PABA) were studied in patients with diabetes mellitus before, during and after various types of treatment. These results were also compared with those in alloxanized animals. The therapeutic significance of these metabolic abnormalities were also discussed. Metabolism of α-keto acids in patients with diabetes mellitus. 1) The ratio of the increase of urinary pyruvate and α-ketoglutarate in the 1st resp. 2nd hour following fructose administration to that in the fasting state was significantly higher in diabetics than in normals. 2) These abnormalities were more marked in cases complicated with hypertension or arteriosclerosis than in those without these complications. 3) Positive correlation was found between fasting blood sugar level and the ratio of urinary α-keto acids in the 2nd hour following fructose administration.
一般社団法人日本内分泌学会の論文