Eremothecium AshbyiiのビタミンB_2生産に關する研究(第27報) : ビタミンB群の成長促進効果

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W.H. SCHOPFEK has reported that biotin is an essential, and vitamin B_1 and mesoinositol are complementary factors for the growth of Eremothecium Ashbyii. However, according to the author's experiments with ammonium sulphate basal medium containing minor asparagine, almost no activity of biotin (free acid) was demonstrated in the absence of meso-insitol (Table 1 and 2)[table 1][table 2]From the data with regard to the activity of vitamin B-complex as growth promoting factor, vitamin B_1,B_6 and pantothenic acid (or its precursor β-alanine) in addition to inositol and biotin were effective, while p-aminobenzoic acid, nicotinamid and folic acid were almost inactive.Furthermore, no growth promoting effect was recognized when all those vitamins except inositol were added, but the growth with inositol alone was no more than quarter of the maximum growth.Therefore, it is concluded that inositol is an essential growth factor, and simultaneously supplementary action of active vitamins is not neglisible.By the addition of these factors to ammonium sulphate basal medium, cultivation of E. As byii could by performed so well as an addition of rice bran extracts and better than peptone basal medium.Neverthless, riboflavin production was almost unaffected so that its yield in contrast to the mycelium growth was rather reduced.
社団法人日本生物工学会の論文
1950-08-15