ラットおよびヒトにおけるα-トコフェロール立体異性体の生体内識別 : 2R,2S体の識別を中心に

概要

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Synthetic α-Tocopherol (α-Toc) contains equal amounts of eight different stereoisomers of α-Toc arising from three asymmetric carbons (2-position in the chroman ring and 4'- and 8'-position in side chain tail). We investigated the distribution and biodiscrimination of α-Toc stereoisomers in rat tissues and in human bloods using a new chiral HPLC method. According to these results, we suggested that 2R-and 2S-isomers were easily transported into the liver from the plasma and the 2R-isomers were preferentially released from the liver into the blood, whereas the 2S-isomers were remained in the liver. In addition, we examined the biodiscrimination of α-Toc stereoisomers during intestinal absorption in situ and in vitro. Consequently, we suggested that the discrimination of α-Toc stereoisomers does not occur during absorption in small intestine. We presumed that this mechanism was performed by α-tocopherol transfer protein (α-TTP) in liver. According to this result, it became clear that a α-TTP was able to discriminate α-Toc stereoisomers, preferentially to transport RRR-α-Toc than SRR-α-Toc from the liposomes.
日本ビタミン学会の論文
1996-07-25