乳酸菌および酵母における抗ビタミンB_6作用の研究 : (II) 2-Ethyl-4-aminopyrimidineおよび2-Methyl-4-aminopyridine誘導体による乳酸菌の増殖抑制

概要

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Eleven derivatives of 2-ethyl-4-aminopyrimidine and two derivatives of 2-methyl-4-aminopyridine were tested for the antivitamin B_6 potency against Lactobacillus arabinosus, Lactobacillus casei, Streptococcus faecalis, and Leuconostoc mesenteroides. Although all samples were not inhibitory to L. arabinosus, 5-CH_2OH-pyrimidine and 5-CH_2Br-pyrimidine were inhibitory to other three organisms. 5-CH_2OH-pyridine, when tested only on Leuc. mesenteroides, was shown to be inhibitory. Recovery of inhibited growth was observed on addition of pyridoxal or pyridoxamine. These compounds were proved to be antivitamin B_6 compounds having mhibitron indices as shown in Table 4,although their potencies were weaker than that of hydroxymethylpyrimidine.
日本ビタミン学会の論文
1969-11-25