高偏極キセノンによるMRI撮像と脳機能計測の可能性について

概要

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It is possible to increase the magnetic polarization of ^<129>Xe by "hyperpolarizing" with an optical pumping method. Furthermore, the T_1 relaxation and chemical shift of xenon are very sensitive to the surrounding environment. Since Xe has a high solubility in blood and lipids, and easily passes through the blood-brain barrier, ^<129>Xe could be a useful MR probe for brain function analysis by studying tissue parameters such as temperature and oxygenation level. To test xenon's potential, we constructed a hyperpolarized gas system and obtained MR spectra from human blood samples using a 4.7 T MRI. We also introduced hyperpolarized ^<129>Xe into an anesthetized rat through a cannula inserted into the trachea. ^<129>Xe spectra were obtained from the rat head with a handmade surface coil.
社団法人日本磁気学会の論文
2004-04-01