歯質アパタイトの結晶成長および非晶質リン酸カルシウムの沈着に及ぼすエナメルタンパク,象牙質リンタンパク,骨コラゲンの効果

概要

論文の詳細を見る
The effects of enamel proteins, dentine phosphoproteins, and bone collagen on the seeded crystal growth of enamel apatite crystals and on the formation of amorphous calcium phosphate were studied in stable supersaturated and unstable supersaturated solutions, respectively, at pH 7.4 and 37℃. Of the two major protein classes in the enamel matrix, enamelins were much potent than amelogenins in retarding seeded growth. However, the amelogenin species that showed significant inhibitory activity are those known to be lost first from the enamel matrix during the rapid mineralization stage of enamel maturation. When compared to the enamel proteins, dentine phosphoproteins and egg yolk phosvitin were found to be up to 8 times more effective in reatrding crystal growth kinetics, whereas bone collagen showed no effect on this seeded growth kinetics at μM concentrations. None of the proteins tested accelerated the formation of amorphous calcium phosphate in unstable supersaturated solutions. This finding may suggest that they play no positive role in the initiation of mineralization in hard tissues.
1985-04-05