Molecular Basis of Voltage-Dependent HERG Channel Block by Class III Drugs
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概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2003-03-01
著者
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Niwa Ryoko
Research Institute of Environmental Medicine, Nagoya University
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Honjo Haruo
Research Institute of Environmental Medicine, Nagoya University
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Kamiya Kaichiro
Research Institute of Environmental Medicine, Nagoya University
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Niwa Ryoko
名古屋大学環境医学研究所 心･血管
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Niwa R
Department Of Cardiovascular Research Research Institute Of Enviromental Medicine Nagoya University
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Niwa Ryoko
名古屋大学環境医学研究所
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Kamiya K
Division Of Cardiovascular Research Reseearch Institute Of Environmental Medicine Nagoya University
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Shimizu Atsuya
Departments of Cardiovascular Research, Nagoya University
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Honjo Haruo
Research Institute Of Environmental Medicine Nagoya University
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Kamiya Kaichiro
Research Institute Of Environmental Medicine Nagoya Univerisyty
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Shimizu Atsuya
名古屋大学 医学系研究科循環器学
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Shimizu Atsuya
Departments Of Cardiovascular Research Nagoya University
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Shimizu Atsuya
Research Institute of Environmental Medicine, Nagoya University
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Honjo Haruo
Research Institute for Environmental Medicine, Nagoya University
関連論文
- Dynamics of Functional Reentry in 2-Dimensional Ventricular Myocardium with Uniform Anisotropy : A High-Resolution Optical Mapping Analysis
- Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle
- Preferential suppression of the longitudinal conduction by Na^+ channel blockade serves a substrate for spiral reentry in the ventricle
- Decreased Vagal Control Over Heart Rate in Rats With Right-Sided Congestive Heart Failure : Downregulation of Neuronal Nitric Oxide Synthase
- Virtual Electrode Polarization-Induced Reentrant Activity
- Pre- and Post-ganglionic Vagal Control of Heart Rate in Rats with Right Ventricular Heart Failure
- Functional roles of I_ and I_ on spatial and frequency-dependent modulation of repolarization in ventricular myocytes
- A high-resolution mapping and analysis system of action potentials during vortex-type arrhythmias
- High-resolution Oprical Mapping System with High-speed Digital Video Camera
- PE-010 Moderate Hypothermia Destabilized Spiral Waves without Widening Excitable Gap in Favor of Self-termination of Ventricular Tachycardia/Fibrillation(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese C
- Modulation of Spiral Wave Reentry by K^+ Channel Blockade(Mechanisms and Future Challenge)
- PE-017 Moderate Hypothermia Causes Destabilization of Rotors without Wavelength Shortening in Favor of VT/VF Self-Termination(Arrhythmia, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-149 Pacing-Induced Heart Failure in Rabbits Accelerates Subepicardial Ventricular Repolarization in Favor of Mother Rotor-Type Ventricular Fibrillation(Arrhythmia, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-330 Concentration-dependent Modification of Spiral-wave Reentry by Verapamil in a Perfused 2-dimensional Layer of Rabbit Ventricular Myocardium(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the
- PE-328 Heavy Ion Radiation Upregulates Connexin43 and Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- OE-238 Mechanisms of Global and Regional Cooling-Assisted Defibrillation in a Bidomain Ventricular Model(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Combined Effects of Nifekalant and Lidocaine on the Spiral-Type Re-Entry in a Perfused 2-Dimensional Layer of Rabbit Ventricular Myocardium
- Electrical Inhomogeneity and Instability of Rabbit Ventricles after Non-Transmural Myocardial Infarction : A High-Resolution Optical Mapping Analysis(Arrhythmia, Basic 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Heavy Ion Radiation Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, Basic 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Acute Amiodarone Suppresses Action Potential Alternans in the Two-dimensional Ventricular Myocardium of Rabbit Hearts(Arrhythmia, Basic 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Action Potential Dynamics of Spiral-type Reentry in 2-Dimensional Anisotropic Layer of Ventricular Muscle : Optical Mapping Analysis Using High-fidelity CMOS Camera(Arrhythmia, Basic 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Right Ventricular Septal Pacing Preserves Long-Term Left Ventricular Function Via Minimizing Pacing-Induced Left Ventricular Dyssynchrony in Patients With Normal Baseline QRS Duration
- PJ-556 Intercellular Uncoupling Stabilizes Spiral-wave Reentry in Favor of its Persistence(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-428 β-Adrenergic Effects on the Dynamics of Spiral Wave Reentry in Langendorff-Perfused Rabbit Hearts(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-054 Bepridil Destabilizes Spiral-Wave Reentry in Favor of Its Early Termination through Tremendous Drift of Rotation Center(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeti
- Internalization and Dephosphorylation of Connexin43 in Hypertrophied Right Ventricles of Rats With Pulmonary Hypertension
- Pathophysiological Significance of T-type Ca^ Channels : Expression of T-type Ca^ Channels in Fetal and Diseased Heart
- PE-035 Association of Renal Artery Stenosis with Anemia and Heart-type Fatty Acid Binding Protein(PE006,Kidney/Renal Circulation/CKD 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- DPE-017 Verapamil Remodels Paroxysmal Atrial Fibrillation via Acceleration of Fibrillation Frequency and Elimination of Pulmonary Vein-to-Left Atrial Frequency Gradient(DPE03,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Digital Poster Sessi
- DPE-016 Possible Mechanism for Defibrillation of Long-Lasting Persistent Atrial Fibrillation with Bepridil(DPE03,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanes
- OJ-157 MK Gene Transfer Causes Amelioration of Cardiac Remodeling after Myocardial Infarction through Enhancements of Neovascularization and Cell Survival(OJ27,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (Japanes
- OE-427 Ventricular Fibrillation in CHF is Characterized by the Existence of Multiple High-frequency Rotating Activities(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-284 Bachmann's Bundle Pacing Ameliorates Efficacy of Cardiac Resynchronization Therapy via Achieving Atrial Mechanical Synchronization(OE48,CRT (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Sarcoplasmic Reticulum Calcium Release Does Not Play a Dominating Role in Sinoatrial Node Pacemaker Activity
- Role of Ca^ Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node
- Rapid Stimulation-induced Abnormal Automaticity at the Junction between Pulmonary Veins and Atria Treatment with Ryanodine
- The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle
- Spontaneous Action Potentials Depend on Both Na^+ and Ca^ Channels in the Embryonic Mouse Heart at Early Stage of Development
- OE-269 Bepridil Reduces Dilatation-induced Vulnerability to Atrial Fibrillation in Rabbit Hearts through Prevention of Refractory Period Shortening and Heterogeneous Intraatrial Conduction(Arrhythmia, basic-2, The 71st Annual Scientific Meeting of the Jap
- OJ-160 Midkine Prevents the Cardiac Remodeling in Mice after Myocardial Infarction and Improves their Long-term Survival(Chronic coronary heart disease/Remodeling-2 (IHD) OJ27,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of
- Subtype Switching of L-Type Ca^ Channel From Ca_v1.3 to Ca_v1.2 in Embryonic Murine Ventricle
- Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
- De-differentiation is a mechanism of electrical-remodeling in diseased hearts
- FRS-051 Role of Ca^-activated Signals and Ca^-handling Protein Phosphorylation Abnormalities in Electrical Storm(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of T
- OJ-069 Effect of 1-week Administration of Calmodulin Antagonist W-7 in a New Experimental Model of Electrical Strom(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-146 Overexpression of Calmodurin Induces Transcriptional Downregulation of Kv4.2 and KChIP2 Channel Subunits in the Transgenic Mouse Heart.(Arrhythmia, basic(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulati
- FRS-031 Midkine Prevents Cardiac Remodeling in Rabbit Congestive Heart Failure through Its Anti-apoptotic Effect(FRS7,Challenging Approaches to Heart Failure Treatment (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japan
- PJ-204 Subepicardial Ventricular Muscle in Tachycardia-induced Heart Failure Shows Prominent Rate-dependent Shortening of Action Potential Duration and Reduction of I_(Arrhythmia, basic(05)(A),Poster Session(Japanese),The 72nd Annual Scientific Meet
- OJ-070 Combined Effects of INa and ICa, Blockade on Spiral Wave Reentry in Perfused 2-dimensional Layer of Rabbit Ventricular Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-160 Comparative Analysis of Dual Actions of Nifekalant on I_(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-131 IKr Blocker Induces Interventricular APD Dispersion and Leads to Spiral Wave-type Polymorphic VT, But IKs Blocker Does Not in Rabbits(Arrhythmia, basic-3 (A) PE22,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japane
- Abnormal automaticity induced by rapid stimulation in myocardial sleeves of rabbit pulmonary veins treated with ryanodine
- Sustained Monomorphic Ventricular Tachycardia in the Two-dimensional Left Ventricular Epicardial Sheets of Rabbit Hearts Perfused In-vitro
- Low-frequency Extracellular Potentials Recorded from the Sinoatrial Node
- PE-009 Acute amiodarone slows down the spiral rotation and prevents the wave-break during ventricular tachycardia(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
- PE-008 Effects of Nifekalant Hydrochrolide on the Spiral-type Functional Reentry in 2-Dimensional Rabbit Ventricular Myocardium(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
- ACUTE AND CHRONIC EFFECTS OF AMIODARONE ON ACTION POTENTIAL AND IONIC CURRENTS IN SINGLE RABBIT VENTRICULAR MYOCYTES
- IS083 Complexity in the regulation of cardiac voltage-gated K+ channel expression by myocardial hypertrophic factors
- IS087 Regional differences of the delayed rectifier K^+ current components (l_ and l_) in rabbit ventricular apical and basal myocytes
- PE-015 Drug-Trapping May Determine the Potency of hERG Block(Arrhythmia, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-236 Coassembly of KCNE1 Alters the Putative Binding Site of Azimilide on KCNQ1 Channels(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Voltage-Dependent Effects of Amiodarone on D540K HERG Channels
- Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channels
- Molecular Basis of Voltage-Dependent HERG Channel Block by Class III Drugs
- Effects of Dronedarone on HERG and KCNQ1/KCNE1 Channel
- Voltage-Dependent Effects of Bepridil on D540K HERG Channels
- Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction
- mRNA Levels of ERG, KVLQT1 and minK in Rabbit Right and Left Ventricles
- Differences in Delayed Rectifier K^+ Currents between Right and Left Ventricles
- 〈SHORT REPORTS〉I_〈Ks〉Block Produces Different Effects on Action
- Remodeling of Ventricular Myocytes in Rabbits with Pacing-Induced Heart Failure
- IS023 Cell-cell communication prevents apoptosis of cultured myocytes
- L-type Ca^ Current in Sphingosine-treated Cultured Rat Ventricular Myocytes
- PE-012 Arrhythmogenic Substrates in the Epicardial Borderzone of Rabbit Hearts after Myocardial Infarction : A High-Resolution Optical Mapping Analysis(Arrhythmia, Basic 3 (A) : PE2)(Poster Session (English))
- Mechanisms of destabilization and early termination of spiral-wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant
- Upregulation of KCNE1 Induces QT Interval Prolongation in Patients With Chronic Heart Failure
- Computer Simulation Analysis of Shock Intensity - and Phase - Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle
- 〈SHORT REPORTS〉Diverse Effects of Pinacidil and Diazoxide on
- A structural basis for drug-induced long QT syndrome
- Effects of Isoproterenol on Ventricular Vulnerability
- Optical recording of action potentials from isolated rabbit hearts subjected to high-intensity DC field stimulation
- Structural Basis of Class III Antiarrhythmic Drug Binding to HERG Channels
- 0719 The effect of thyroid hormone on the expression of K^+ channel gene expression in rat heart
- Limited Association of Connexin43 and ZO-1 in the Intercalated Disks of Adult Rat Ventricular Myocrdium
- Internalization and Dephosphorylation of Connexin43 Gap Junctions in Hypertrophied Rat Ventricular Myocytes(RIEM Conference II, 2002)
- Dephosphorylation of Connexin43 Associated with Ventricular Hypertrophy
- Internalization of connexin43 gap junctions in hypertrophied rat ventricular myocytes
- Upregulation of minK gene causes QT prolongation in human
- 〈SHORT REPORTS〉Analysis of Epicardial Activation Patterns during
- Effects of Disopyramide on the Reentrant Polymorphic
- Effects of nifedipine on the extracellular potentials recorded from the sinoatrial node in rabbit hearts
- MinK attenuates I_ block by bepridil
- Differential Effects of Bepridil on HERG and KvLQT1/mink Channels
- 〈SHORT REPORTS〉Differential Effects of Vesnarinone on HERG and
- Chronic Effects of Amiodarone on Delayed Rectifier
- Gap junction remodeling in hypertrophied cardiac muscle
- PE-267 Electrophysilogy of Myoblast and Myotube Isolated from Mouse Leg(Transplantation 1 (M) : PE46)(Poster Session (English))
- Imaging of Mitochondrial Ca^ Concentration in Saponin Permeabilized Rat Ventricular Myocytes
- Optical Mapping of Ventricular Tachyarrhythmias(Morning Lecture 14 (ML14) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Appropriate Approaches for Pharmacological Management of Atrial Fibrillation Based on Pathogenesis and Basic Electrophysiology