Relationships of Nutrient Intake and Lifestyle-Related Factors to Serum Folate and Plasma Homocysteine Concentrations in 30-69 Year-Old Japanese

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概要

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• We studied non-hospitalized 30-69 y-old Japanese subjects to ascertain the influences of a 677C-T methylene-tetrahydrofolate reductase (MTHFR) genotype, nutritional intake and lifestyle-related factors on plasma homocysteine (Hcys) and serum folate concentrations. Hcys was higher and serum folate was lower in males than in females (p<0.01). The Hcys concentration was higher in the VV group than in the AA and AV groups for both males and females. However, a relatively low serum folate concentration of 18±7 nmol/L was found in the entire male group as compared with 22±10 nmol/L in all females. In the female subjects, serum folate concentrations differed among MTHFR genotypes, being lowest in the VV group. In all male subjects, log folate intake per 1,000 kcal was a significant positive predictor of log serum folate concentration (p<0.01), while in females the log vitamin C intake per standard body weight was a significant positive variable (p<0.001) predicting the log serum folate concentration. Smokers had significantly lower serum folate concentrations, regardless of dietary folate intake. High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations. Even a 400 μg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration.

• 日本ビタミン学会の論文

著者

• Tsushima Motoo

  Department of Internal Medicine, Keio University School of Medicine

• Nakano Satomi

  Department of Internal Medicine, Keio University School of Medicine

• Maruyama Taro

  Department of Internal Medicine, Keio University School of Medicine

• Kyotani Shingo

  Department of Internal Medicine, Keio University School of Medicine

• 中西 守

  愛知学院大薬

• 中西 守

  名市大・薬

• MARUYAMA Chizuko

  Department of Food and Nutrition, Japan Women's University

• Tsushima Motoo

  Department Of Internal Medicine Keio University School Of Medicine

• Maruyama C

  Department Of Food And Nutrition Japan Women's University

• Maruyama Taro

  九州大学 医学研究院臨床薬理学

• Miwa Yoshikazu

  Dep. Of Clinical Pharmacology Fac. Of Medical Sciences Kyushu Univ. Jpn

• Miwa Yoshikazu

  Department Of Clinical Pharmacology Graduate School Of Medical Sciences Kyushu University

• Kyotani Shingo

  Department Of Food And Nutrition Japan Women's University

• Kyotani Shingo

  九州大学 医学研究院臨床薬理学

• Nakano Satomi

  九州大学 医学研究院臨床薬理学

• Nakano Satomi

  Department Of Internal Medicine Keio University School Of Medicine

• ARAKI Risa

  Department of Food and Nutrition, Japan Women's University

• TAKEUCHI Mayako

  Department of Food and Nutrition, Japan Women's University

• KUNIYOSHI Eriko

  Department of Food and Nutrition, Japan Women's University

• IWASAWA Akiko

  Department of Food and Nutrition, Japan Women's University

• MOTOHASHI Yoshiko

  Department of Internal Medicine, Keio University, School of Medicine

• NAKANISHI Mamoru

  Department of Clinical Pathology, Hyogo Medical College

• Maruyama Chizuko

  日本女子大学 家政学部食物学科

• Maruyama Chizuko

  Department Of Food And Nutrition Japan Women's University

• Motohashi Y

  Department Of Internal Medicine Keio University School Of Medicine

• Motohashi Yoshiko

  慶応義塾大学 医学部

• Nakanishi Mamoru

  愛知学院大学 薬学部

• Nakanishi M

  School Of Pharmacy Aichi Gakuin University

• Araki Risa

  日本女子大学 家政学部食物学科

• Araki Risa

  Department Of Food And Nutrition Japan Women's University

• Iwasawa Akiko

  Department Of Food And Nutrition Japan Women's University

• Takeuchi Mayako

  Department Of Food And Nutrition Japan Women's University

• Takeuchi Mayako

  日本女子大学 食物・栄養学

• Kyotani Shingo

  Department Of Cardiology National Cardiovascular Center

• Tsushima Motoo

  Department Of Atherosclerosis And Metabolism

• Kuniyoshi Eriko

  Department Of Food And Nutrition Japan Women's University

• Maruyama Taro

  Department Of Internal Medicine Saitama Social Insurance Hospital

• Nakanishi Mamoru

  Department Of Clinical Pathology Hyogo Medical College

• Motohashi Yoshiko

  Department Of Clinical Pharmacology Faculty Of Medical Sciences Kyushu University

• Nakanishi Mamoru

  Sch. Pharma. Aichi-gakuin Univ.

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