Timing of Anti-Platelet Effect After Oral Aspirin Administration in Patients With Sympathetic Excitement
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概要
- 論文の詳細を見る
Aspirin is used in percutaneus coronary interventions (PCI) for acute myocardial infarction (AMI) to prevent thrombosis. It is reported that the aspirin concentration in blood reaches its peak approximately 20min after oral administration in healthy volunteers, but the absorption and bioavailability of aspirin in AMI may be quite different. In the present study patients undergoing coronary angiogram for the first time were enrolled as a model of sympathetic excitement and the timing of the antiplatelet effect after oral aspirin administration was investigated. Aspirin (162mg) was administered to the patients in a catheter laboratory. Platelet count, aspirin concentration, and platelet aggregation were measured at scheduled timepoints before and up to 120min. Ticlopidine was administered in the same procedure, and platelet count and platelet aggregation were evaluated at 0 and 120min. There was no significant change in the platelet count. Aspirin concentration in blood had not reached its peak by 120min. Platelet aggregation induced by collagen or ADP began to be inhibited 45min after aspirin administration. No significant inhibition of platelet aggregation was observed up to 120min following ticlopidine administration. During sympathetic excitement, aspirin absorption and its antiplatelet effect were significantly delayed in these patients. Ticlopidine did not show any antiplatelet effect by 120min. For PCI performed in a patient with a high level of sympathetic excitement, aspirin should be administered at least 45min before the first balloon dilatation.
- 社団法人日本循環器学会の論文
- 2003-07-20
著者
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Tsushima Motoo
Department of Internal Medicine, Keio University School of Medicine
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Tsushima Motoo
Department Of Internal Medicine Ise-keio Hospital Keio University
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Tsushima Motoo
Department Of Atherosclerosis And Metabolism
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NISHIYAMA Atsushi
Department of Pediatrics, Graduate School of Medicine Kobe University
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Nishiyama Atsushi
Department Of Internal Medicine Ise-keio Hospital Keio University
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Mohri Hiroshi
Department Of Internal Medicine Ise-keio Hospital Keio University
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Niikawa Osamu
Department of Internal Medicine, Ise-Keio Hospital, Keio University
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Nishiyama Atsushi
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Niikawa Osamu
Department Of Internal Medicine Ise-keio Hospital Keio University
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Niikawa Osamu
Department Of Internal Medicine And The Department Of Ophthalmology Keio University Ise Keio Hospita
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MOHRI Hiroshi
Department of Hematology, Showa University Fujigaoka Hospital
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