Association Between Small Dense Low-Density Lipoprotein and Postprandial Accumulation of Triglyceride-Rich Remnant-Like Particles in Normotriglyceridemic Patients With Myocardial Infarction

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概要

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• Background Although the small dense low-density lipoprotein (sd-LDL) is associated with hypertriglyceridemia, more than 60% of myocardial infarction (MI) patients are normotriglyceridemic in the fasting state. This study was aimed to investigate the relationship between the low-density lipoprotein (LDL) phenotype and postprandial hyperlipemia (PPL) in MI patients. Methods and Results Oral fat tolerance tests were performed in 71 patients with acute MI and fasting triglyceride concentrations below 200mg/dl. Postprandial changes in the LDL particle diameter (LDL-PD) and lipids over a 6-h period after a meal were compared among 4 groups of patients classified according to fasting triglyceride levels (A, B as <150, and C, D as ≥150) and postprandial triglyceride levels (A, C as <230 and B, D as ≥230). Although fasting concentrations of triglyceride and remnant-like particle (RLP)-triglyceride were significantly higher in group C than in group B, the areas under the curves of the RLPs were significantly higher in group B. The triglyceride-to-cholesterol ratio in the RLPs was significantly higher in the PPL group than in the nonPPL group postprandially. The prevalence of sd-LDL (LDL-PD ≤25.5nm) was significantly higher in group D but similar between groups B and C (23%, 42%, 50% and 83% in groups A, B, C and D, respectively). Conclusion These results suggest that postprandial accumulation of triglyceride-rich lipoproteins is strongly associated with sd-LDL in MI patients without hypertriglyceridemia.

• 社団法人日本循環器学会の論文
• 2004-11-20

著者

• Geshi Eiichi

  Third Dept. of Internal Medicine, Showa University

• Katagiri Takashi

  Third Dept. of Internal Medicine, Showa University

• Tsunoda Fumiyoshi

  Third Department of Internal Medicine, Showa University School of Medicine

• Koba Shinji

  Third Department of Internal Medicine, Showa University School of Medicine

• Ban Yoshihisa

  Third Department of Internal Medicine, Showa University School

• Suzuki Hiroshi

  Third Department of Internal Medicine, Showa University School

• Hirano Tsutomu

  First Deparment of Internal Medicine, Showa University School of Medicine

• Iso Yoshitaka

  Third Department Of Internal Medicine Showa University School Of Medicine

• Hirano Tsutomu

  Department Of Medicine Division Of Diabetes Metabolism And Endocrinology Showa University School Of

• Hirano Tsutomu

  Division Of Diabetes Metabolism And Endocrinology Department Of Medicine Showa University School Of

• Hirano Tsutomu

  First Department Of Internal Medicine Showa University School Of Medicine

• Tanno Fumihiro

  Department Of Medicine Division Of Cardiology Showa University School Of Medicine

• Ban Yoshihisa

  Division Of Diabetes Metabolism And Endocrinology Department Of Medicine Showa University School Of

• Katagiri Takashi

  Department Of Medicine Division Of Cardiology Showa University School Of Medicine

• Suzuki Hiroshi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Katagiri Takashi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Geshi Eiichi

  Department Of Medicine Division Of Cardiology Shown University School Of Medicine

• Hirano Tsutomu

  Department Of Diabetes Metabolism And Endocrinology Showa University School Of Medicine

• Katagiri Takashi

  Third Department Inter Nat Medicine Showa University

• Geshi Eiichi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Hirano Tsutomu

  Department Of Diabetes Metabolism And Endocrinology Showa University

• Hirano Tsutomu

  Division Of Diabetes Metabolism And Endocrinology Department Of Medicine Showa University School Of Medicine

• Koba Shinji

  Third Department Of Internal Medicine Showa University School Of Medicine

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