Promoter Polymorphism of the β_2 Bradykinin Receptor Gene is Associated With Essential Hypertension

概要

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The present study examined the genetic contribution of the human β_2 bradykinin receptor gene in Japanese subjects with essential hypertension, and identified a-58T/C polymorphism of the core promoter that might be responsible for essential hypertension in Japanese. The study consisted of 100 hypertensive subjects and 100 age- and sex-matched controls. The allelic frequencies were 0.575 for the C allele and 0.425 for the T allele in hypertensive subjects, and 0.465 for the C allele and 0.535 for the T allele in normotensive subjects. The allelic frequencies were in Hardy-Weinberg equilibrium. Significant differences between hypertensive and normotensive subjects were seen in the genotypes distribution(p=0.049)and allelic frequencies(p=0.028), and the β_2 bradykinin receptor gene variant was associated with human essential hypertension in this Japanese population. This new marker may provide a valuable tool for assessing the risk for putative bradykinin-associated common diseases, such as hypertension, and cardiovascular diseases with genetic determinism. These results suggest that the -58 polymorphism of the human β_2 bradykinin receptor gene is an independent risk factor for essential hypertention in the Japanese population.
1999-09-20