Protection of Acute Ischemic Myocardial Injury by Pharmacological Intervention : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacological protection of acute ischemic myocardial injury was studied using diltiazem, bunazosin, coenzyme-Q_<10> (Co-Q), and nicorandil, in dogs of which the left anterior descending coronary artery was ligated for 60 min. Drugs were given intravenously prior to and/or during coronary ligation. Co-Q, bunazosin and diltiazem suppressed degradation of sarcoplasmic reticulum (SR) expressed as inhibitions of reduction in Ca^<++>-dependent ATPase activity and degradation of major ATPase protein. Fine structures of ischemic myocardial cells were simultaneously retained as well. On the contrary, the effects of nicorandil on ischemic myocardial injury were few. It is likely that protection of ischemic myocardial injury could be expected with drugs which react with ischemic myocardium directly and inhibit excess inflow of extracellular Ca^<++> in ischemic myocardium.
- 社団法人日本循環器学会の論文
- 1989-09-20
著者
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Umetsu Kazuhiko
Third Dept. of Internal Medicine, Showa University
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Geshi Eiichi
Third Dept. of Internal Medicine, Showa University
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Katagiri Takashi
Third Dept. of Internal Medicine, Showa University
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KONNO Noburu
Third Department of Internal Medicine, Showa University School of Medicine
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Umetsu Kazuhiko
Third Department Of Internal Medicine Showa Univirsity School Of Medi Cine
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Umetsu Kazuhiko
Third Department Of Internal Medicine. Showa University School Of Medicine
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Komo Noburu
The Third Department Of Internal Medicine School Of Medicine Showa University
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Hiroshige Juichi
Third Department of Internal Medicine, Showa University
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Mochizuki Mamoru
Third Department of Internal Medicine, Showa University School of Medicine
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Mochizukl Mamoru
The Third Department Of Internal Medicine Showa Universty School Of Medicine
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Katagiri Takashi
Third Department Of Internal Medicine Showa University School Of Medicine
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Mochizuki Mamoru
The Third Department Of Internal Medicine Showa Universty School Of Medicine
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Hiroshige Juichi
Third Depertment Of Internal Medicine Showa University School Of Medicine
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Katagiri Takashi
Third Department Inter Nat Medicine Showa University
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Geshi Eiichi
Third Department Of Internal Medicine Showa University School Of Medicine
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