ALTERATIONS IN PHOSPHOLIPIDS IN ACUTE ISCHEMIC MYOCARDIUM
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概要
- 論文の詳細を見る
Alterations in the phospholipid component of membranes were studied in acute myocardial ischemia with respect to sarcoplasmic reticulum (SR) and mitochondria (Mt) in the carine heart and compared with changes in the phospholipid composition of intact membrane treated with exogenous phospholipases (PLases)A_2 and C, in order to examine the mechanism of ischemic degradation. As early as 30 min after coronary ligation, the total phospholipid content of SR and Mt decreased significantly, 16.0% and 5.6% respectively. The patterns of SR and Mt phospholipids from the ischemic myocardia did not differ on the chromatograms from those of the non-ischemic myocardia, and no significant increases in lysophospholipids were found for up to 3 hrs. Among the components of phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) decreased mainly during ischemia, and depletion of PC exceeded that of PE in SR. PLase C hydrolysed phospholipids yielded no lysophospholipids, compared to the production of a large amount of lysophospholipids by PLase A_2. It was concluded that degradation of membrane phospholipids occurs in the early stage of myocardial ischemia mainly in PC and PE, which are the major components of membrane phospholipids. This may be an expression of irreversible changes, and the activation of PLase C was considered to play an important role in their degradation.
- 社団法人日本循環器学会の論文
- 1987-01-20
著者
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Geshi Eiichi
Third Dept. of Internal Medicine, Showa University
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Komo Noburu
The Third Department Of Internal Medicine School Of Medicine Showa University
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KONNO NOBORU
Third Department of internal medicine, Showa University School of Medicine
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Katagiri Takashi
Third Department Of Internal Medicine Showa University School Of Medicine
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Yanagishita Toshikuni
The Third Department Of Internal Medicine School Of Medicine Showa University
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Yanagishita Toshikuni
Third Department Of Internal Medicine Showa University School Of Medicine.
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Yanagishita Toshikuni
昭和大学 第3内科
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Katagiri Takashi
Third Department Inter Nat Medicine Showa University
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Geshi Eiichi
Third Department Of Internal Medicine Showa University School Of Medicine
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