Alterations in Sarcoplasmic Reticulum and Angiotensin II Type 1 Receptor Gene Expression After Myocardial Infarction in Rats

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概要

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• The purpose of this study was to investigate the function of sarcoplasmic reticulum(SR)and the role of angiotensin II type 1 receptor(AT1)in ventricular remodeling in non-infarcted areas after myocardial infraction(MI).MI was produced in anesthetized Sprague-Dawley rats(10-12 weeks old)by ligation of the left anterior descending coronary artery.Four weeks after MI, hemodynamic measurements were performed.SR Ca^2+-ATPase activity and mRNA(SERCA2a)and AT1 mRNA(AT1a, AT1b)were analyzed.Left ventricular enddiastolic pressure was higher and left ventricular dp/dt was significantly lower in the MI group.In non-infarcted areas in the MI group, myocardial transverse diameter was significantly greater and both Ca^2+-ATPase activity in the SR and SERCA2a level decreased.The AT1a level was higher in non-infarcted areas than in controls, whereas the AT1b mRNA expression level was unchanged.These results suggest that, in the ventricular remodeling after MI, alterations in SR protein and its mRNA in non-infarcted myopcardium help initiate heart failure and that Ca overload caused by the up-regulation of AT1a mRNA is an important cause of alteration in SR function.

• 社団法人日本循環器学会の論文
• 1998-05-20

著者

• Geshi Eiichi

  Third Dept. of Internal Medicine, Showa University

• Katagiri Takashi

  Third Dept. of Internal Medicine, Showa University

• Nomizo Akihiko

  Third Department of Internal Medicine, Showa University School of Medicine

• Iijima Katsumichi

  Third Department of Internal Medicine, Showa University School of Medicine

• Arata Yoshihisa

  Third Department of Internal Medicine, Showa University School of Medicine

• Nomizo Akihiko

  Third Department Of Internal Medicine Showa University School Of Medicine

• Arata Yoshihisa

  Third Department Of Internal Medicine Showa University School Of Medicine

• Katagiri Takashi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Iijima Katsumichi

  Third Department Of Internal Medicine Showa University School Of Medicine

• Kitsu Tooru

  Third Department Of Internal Medicine Showa University School Of Medicine

• Kusuyama Taro

  Department Of Medicine Division Of Cardiology Showa University School Of Medicine

• Katagiri Takashi

  Third Department Inter Nat Medicine Showa University

• Geshi Eiichi

  Third Department Of Internal Medicine Showa University School Of Medicine

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