Detection of Anti-Topoisomerase I Autoantibody in Patients with Silicosis

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概要

• 論文の詳細を見る

• Objectives : The aim of this study was to detect anti-topoisomerase 1(anti-topo I) autoantibodies, which are known to be limited in systemic sclerosis patients, in silicosis patients with no clinical symptoms of autoimmune disease. Methods : Serum anti-topo I autoantibodies were detected using ELISA. Differences in clinical parameters between patients with and without anti-topo I autoantibodies were analyzed. Results : Seven of 69 patients had anti-topo I autoantibodies. These 7 patients showed elevated PaCO_2 values (P=0.0212), and inverse correlations between serum soluble Fas levels and PaCO_2 values were found. Conclusion : Anti-topo I autoantibodies were detected in 10.1% of silicosis patients without any clinical symptoms of autoimmune disease. The findings here suggest that the genesis of anti-topo I autoantibodies might be related to pulmonary involvement or lung fibrosis associated with progression of silicosis.

• 日本衛生学会の論文

著者

• UEKI Ayako

  Department of Hygiene, Kawasaki Medical School

• OTSUKI Takemi

  Department of Hygiene, Kawasaki Medical School

• Ueki A

  Department Of Rehabilitation Faculty Of Health Science And Technology Kawasaki University Of Medical

• Ueki Ayako

  川崎医科大学 衛生学教室

• Ueki Ayako

  川崎医療福祉大学

• Hyodoh Fuminori

  Department of Hygiene, Kawasaki Medical School

• Otsuki T

  Department Of Hygiene Kawasaki Medical School

• Otsuki Takemi

  Department Of Hygiene Kawasaki Medical School

• SAKAGUCHI Haruko

  Department of Hygiene, Kawasaki Medical School

• Ueki A

  Kawasaki University Of Medical Welfare

• Ueki Ayako

  Department Of Hygiene

• Ueki Ayako

  Department Of Anatomy Okayama University Medical School

• ISOZAKI Yumika

  Department of Hygiene, Kawasaki Medical School

• KUSAKA Masayasu

  Department of Medicine, Kusaka Hospital, Japan

• KUSAKA Masayasu

  Kusaka Hospital

• Isozaki Yumika

  Department Of Hygiene Kawasaki Medical School

• Hyodoh Fuminori

  The First Department Of Nursing Kawasaki College Of Allied Health Professions

• Hyodoh Fuminori

  Department Of Hygiene Kawasaki Medical School

• TOMOKUNI Akiko

  Department of Hygiene, Kawasaki Medical School

• Kusaka Masayasu

  Department Of Medicine Kusaka Hospital Japan

• Kusaka Masayasu

  Department Of Internal Medicine Kusaka Hospital

• Sakaguchi Haruko

  Department Of Hygiene

• Takata Akiko

  Department Of Hygiene Kawasaki Medical School

• Ishii Yasuhisa

  Department Of Surgery Nihon University School Of Medicine

• Sakaguchi H

  Department Of Hygiene

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