Anti-Caspase-8 Autoantibody Response in Silicosis Patients is Associated with HLA-DRB1, DQB1 and DPB1 Alleles

スポンサーリンク

概要

• 論文の詳細を見る

• Anti-Caspase-8 Autoantibody Response in Silicosis Patients is Associated with HLA-DRB1, DQB1 and DPB1 Alleles: Ayako UEKI, et al. Kawasaki University of Medical Welfare-We reported previously the autoantibodies directed to caspase-8 among patients with silicosis, systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) , and in healthy individuals. In this study, we analyzed the correlation between anti-caspase-8 autoantibody responses and HLA class II alleles in silicosis patients. The frequencies of HLA-DRB1*0406 were significantly higher in antibody positive patients (16.67%) than in control individuals (3.03%, p=0.0006). The lysine (K) at position 71 as in DRB1*0406 has been reported to be associated with rheumatoid arthritis (RA) and insulin dependent diabetes mellitus (IDDM). The haplotype HLA-DR4; DQB1*0302 was detected in 4 of 12 antibody positive patients. RA, IDDM, or pemphygus vulgaris link to the haplotype. The frequencies of DQB1*0401 were significantly lower in antibody positive patients (0%) than that in controls (13.33%, p=0.0390). The aspartic acid at position 57 in the DQB1 molecule as in DQB1*040 1 is reported to play a role in the resistance to IDDM. The frequency of DPB1*0601 in antibody positive patients (5.88%) was significantly higher than that in controls (0.56%, p=0.0003). DPB1*0601 is reported to be a risk factor among RA patients, and glutamate at position 69 of the DPB1 molecule may be involved. Repeated and continuous screening of autoantibodies seems to be necessary among workers in contact with Si-related substances for the detection of immunological disorders in the early stage.

• 社団法人日本産業衛生学会の論文

著者

• Ueki A

  Department Of Rehabilitation Faculty Of Health Science And Technology Kawasaki University Of Medical

• Ueki Ayako

  川崎医科大学 衛生学教室

• Ueki Ayako

  川崎医療福祉大学

• Ueki A

  Kawasaki University Of Medical Welfare

• UEKI Ayako

  Kawasaki University of Medical Welfare

• ISOZAKI Yumika

  Department of Hygiene, Kawasaki Medical School

• KUSAKA Masayasu

  Department of Medicine, Kusaka Hospital, Japan

• KUSAKA Masayasu

  Kusaka Hospital

• Isozaki Yumika

  Department Of Hygiene Kawasaki Medical School

• Kusaka Masayasu

  Department Of Medicine Kusaka Hospital Japan

• Kusaka Masayasu

  Department Of Internal Medicine Kusaka Hospital

• Ishii Yasuhisa

  Department Of Surgery Nihon University School Of Medicine

関連論文

• Keynote Lecture in the 13^th Japanese Society of Immunotoxicology(JSIT 2006) : Pathophysiological Development and Immunotoxicology : what we have found from the researches related to the silica and silicate such as asbestos
• Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis
• Perturbation of Secretory Ig A in Saliva and Its Daily Variation by Academic Stress
• Cell biological roles of IL-10 in myeloma cells
• Cellular Biological Differnces Between Human Myeloma Cell Lines KMS-12-PE and KMS-12-BM Established From a Single Patient
• Anti-Caspase-8 Autoantibody Response in Silicosis Patients is Associated with HLA-DRB1, DQB1 and DPB1 Alleles
• Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases
• Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients?
• Review of Regulation for the Fas-mediated Apoptotic Pathway in Silicosis Patients
• Detection of Anti-Topoisomerase I Autoantibody in Patients with Silicosis
• Reduced Expression of the Survivin Gene in PBMC from Silicosis Patients
• Reduced Expression of the Inhibitory Genes for Fas-Mediated Apoptosis in Silicosis Patients

もっと見る 閉じる

スポンサーリンク